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topoisomerase-ii
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Acridine derivatives as inhibitors/poisons of topoisomerase II
2022 |
Publication without faculty affiliation
publication
Tacrine derivatives as dual topoisomerase I and II catalytic inhibitors
2015 |
Publication without faculty affiliation
publication
DNA topoisomerase II beta: A player in regulation of gene expression and cell differentiation
2012 |
Faculty of Pharmacy in Hradec Králové
publication
Dual inhibition of topoisomerases enhances apoptosis in melanoma cells
2010 |
Faculty of Medicine in Hradec Králové
publication
Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds
2015 |
Publication without faculty affiliation
publication
Proliferative Markers in Diagnosis of Thyroid Tumors: A Comparative Study of MIB-1 and Topoisomerase II-a Immunostaining
2005 |
First Faculty of Medicine
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Selected ferrocenyl chalcones as DNA/BSA-interacting agents and inhibitors of DNA topoisomerase I and II activity
2018 |
Publication without faculty affiliation
publication
New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds
2016 |
Publication without faculty affiliation
publication
Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation
2021 |
Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
publication
Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite
2017 |
Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
publication
Silver pyridine-2-sulfonate complex - its characterization, DNA binding, topoisomerase I inhibition, antimicrobial and anticancer response
2018 |
Faculty of Science
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Tacrine-Coumarin Derivatives as Topoisomerase Inhibitors with Antitumor Effects on A549 Human Lung Carcinoma Cancer Cell Lines
2021 |
Publication without faculty affiliation
publication
Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity
2016 |
Publication without faculty affiliation
publication
Role of the Water-Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV
2014 |
Central Library of Charles University
publication
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase II beta Interactions
2021 |
Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
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Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity
2020 |
Publication without faculty affiliation
publication
A novel quantitative PCR of proliferation markers (Ki-67, topoisomerase II alpha, and TPX2): an immunohistochemical correlation, testing, and optimizing for mantle cell lymphoma
2010 |
Second Faculty of Medicine
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Inhibitors of topoisomerase I and their significance in oncology.
1998 |
Faculty of Physical Education and Sport
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DNA topoisomerase II-alpha in ovarian carcinoids
Publication without faculty affiliation
publication
Proliferative markers in diagnosis of thyroid tumors: A comparative study of MIB-1 and topoisomerase II-á immunostaining
2005 |
Faculty of Medicine in Pilsen
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DNA topoisomerase II-alpha in pulmonary carcinoid tumors
2001 |
Faculty of Medicine in Hradec Králové
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Topoisomerases and Tubulin Inhibitors: a promising combination for cancer treatment
2003 |
Publication without faculty affiliation
publication
Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc(II) fenamates
2018 |
Faculty of Science
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Catalytic Inhibitors of Topoisomerase II Differently Modulate the Toxicity of Anthracyclines in Cardiac and Cancer Cells
2013 |
Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
publication
DNA topoisomerase II-alpha (Ki-S1) in pulmonary typical and atypical carcinoid tumors
Publication without faculty affiliation
publication
Novel cholinesterase modulators and their ability to interact with DNA
2013 |
Publication without faculty affiliation
publication
Proliferative Markers in Diagnosis of Thyroid Tumors: A Comparative Study of MIB-1 and Topoisomerase II-a Immunostaining
+1
2005 |
Faculty of Medicine in Hradec Králové
publication
Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase II beta inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity
2021 |
Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové
publication
Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase II beta Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity
2020 |
Faculty of Medicine in Hradec Králové, Faculty of Pharmacy in Hradec Králové