1^st Introduction: A brief overview of the development of quality assurance, basic terms of quality management concepts, principles and tools of quality management in an analytical or medical laboratory.

2^nd Quality management systems: basic terms, accreditation, certification, accreditation system for testing and medical laboratories – procedure for accreditation according to ISO/IEC 17025 and ISO 15189 in Czech Republic. Principles of document control. Standard operation procedure (SOP). Risk management. Tasks of quality manager.

3^rd Quality management systems: The OECD Good Laboratory Practice, Good Manufacturing Practice, certification according to ISO 9001, their main features, compared with the accreditation and applications in the analytical or medical laboratory, inclusion in the international framework.

4^th Development and standardization of analytical methods (chemical measurement procedures), using of the standard procedures for routine analyses.

5^th Validation of analytical methods (procedures), validation of instrumentation and software. Verification.

6^th Quality control: aims, tools, types of control samples, proficiency testing, risks.

7^th Control charts: purpose, types, construction, method of use, statistical process control.

8^th Metrology in chemistry, legal metrology, metrological traceability and its specifics in chemistry.

9^th Reference materials (RM), types of RM, usage of RM, comparing the measured and certified values of CRM, commutability of RM.

10^th Instrumentation, confirmation, calibration and qualification of instrumentation. Categorization of measuring devices. Metrological assurance of analytical laboratory.

11^th Uncertainty of the results of analytical measurements: purpose, use, relationship of an error and uncertainty, evaluation ways, presentation of results, the impact of uncertainty on the comparison of a result with limits.