1. Definition of programmed or regulated cell death, its historical and evolution-related aspects and importance for life of an organism. Overview of principles and signalling in various forms of regulated cell death.

2. Caspase-dependent apoptosis: Initiator and effector caspases, their activation, regulation and function.

3. Mitochondria and other organelles in apoptosis; proteins from Bcl-2 family.

4. Intracellular or intrinsic induction of apoptosis, stress response, p53 tumour suppressor.

5. Extracellular or extrinsic induction of apoptosis (death receptors, immune system etc.).

6. Regulated necrosis and other mechanisms of regulated cell death.

7. Final steps in cell destruction, removal of the corpses.

8. Summary of activation and regulation of cell death in mammalian cells.

9. Regulated cell death in other vertebrates and in invertebrates.

10. Regulated cell death in single cell organisms and in plants.

11. Physiology and pathophysiology of regulated cell death; methods of cell death detection and quantification.