Vzácné alelické varianty jako determinanty zásobení foláty v nesuplementované evropské populaci.

Abstrakt

This epidemiological study examined association between twelve genetic variants and folate status in Czech population and discovered a novel MTHFR variant that is associated with increased folate concentrations.

Klíčová slova

• glutamate-carboxypeptidase-ii
• coronary-artery-disease
• one-carbon metabolism
• methylenetetrahydrofolate reductase
• homocysteine concentrations
• genetic-determinants
• common mutation
• serum folate
• polymorphisms
• prevalence