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Multi-target directed ligands
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publication
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
2019 |
Ústřední knihovna, Lékařská fakulta v Hradci Králové
publication
Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy
2021 |
Publikace bez příslušnosti k fakultě
publication
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease
2021 |
Publikace bez příslušnosti k fakultě
publication
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease
2017 |
Publikace bez příslušnosti k fakultě
publication
Riluzole-Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis
2022 |
Publikace bez příslušnosti k fakultě
publication
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
Publikace bez příslušnosti k fakultě
publication
Derivatives of the beta-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease
2019 |
Farmaceutická fakulta v Hradci Králové, Lékařská fakulta v Hradci Králové
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Profiling donepezil template into multipotent hybrids with antioxidant properties
2018 |
Publikace bez příslušnosti k fakultě
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Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
2015 |
Publikace bez příslušnosti k fakultě
publication
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease
2021 |
Publikace bez příslušnosti k fakultě
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Konjugáty na bázi takrinu a tryptofanu, způsob jejich přípravy a jejich použití
Publikace bez příslušnosti k fakultě
publication
Donepezil derivatives targeting amyloid-beta cascade in Alzheimer's disease
2019 |
Publikace bez příslušnosti k fakultě
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Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives
2019 |
Publikace bez příslušnosti k fakultě
publication
Huprine Y-Tryptophan heterodimers with potential implication to Alzheimer's disease treatment
2021 |
Farmaceutická fakulta v Hradci Králové, 1. lékařská fakulta
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The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
2018 |
Farmaceutická fakulta v Hradci Králové
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The pharmacology of tacrine at N-methyl-D-aspartate receptors
2017 |
Publikace bez příslušnosti k fakultě
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Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-D-Aspartate Receptor Antagonists
2021 |
Farmaceutická fakulta v Hradci Králové, Přírodovědecká fakulta
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Structure-Guided Design of N-Methylpropargylamino- Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease
2023 |
Farmaceutická fakulta v Hradci Králové, Přírodovědecká fakulta
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Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
2020 |
Publikace bez příslušnosti k fakultě
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Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment
2017 |
Publikace bez příslušnosti k fakultě
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7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
2015 |
Publikace bez příslušnosti k fakultě
publication
Takrin a jeho deriváty v terapii Alzheimerovy choroby
2012 |
Publikace bez příslušnosti k fakultě
publication
7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer's Disease Treatment - Synthesis, Biological Evaluation and Molecular Modeling Studies
2013 |
Publikace bez příslušnosti k fakultě
publication
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment
2017 |
Publikace bez příslušnosti k fakultě
publication
Novel propargylamine-based inhibitors of cholinesterases and monoamine oxidases: Synthesis, biological evaluation and docking study
2021 |
Farmaceutická fakulta v Hradci Králové
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Multitarget tacrine hybrids with neuroprotective properties to confront Alzheimer's disease
2017 |
Publikace bez příslušnosti k fakultě
publication
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
2019 |
Publikace bez příslušnosti k fakultě
publication
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease
2019 |
Publikace bez příslušnosti k fakultě